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  <doi_batch_id>1fe052d619b7831b5327d90</doi_batch_id>
  <timestamp>20260102112444460</timestamp>
  <depositor>
    <depositor_name>funda:funda</depositor_name>
    <email_address>fundamentalJournals@gmail.com</email_address>
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  <registrant>WEB-FORM</registrant>
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<body>
  <journal>
    <journal_metadata>
  <full_title>International Journal of Fundamental Physical Sciences</full_title>
  <abbrev_title>IJFPS</abbrev_title>
  <issn media_type='electronic'>22318186</issn>
</journal_metadata>
<journal_issue>
  <publication_date media_type='online'>
    <month>12</month>
    <year>2025</year>
  </publication_date>
  <journal_volume>
    <volume>15</volume>
  </journal_volume>
  <issue>4</issue>
</journal_issue><!-- ============== -->
<journal_article publication_type='full_text'>
  <titles>
  <title>A Theoretical Framework for Selective Trapping of Irradiated Metal Complexes in Cancer Cells via Flux-Guided Membrane Energetics</title>
  </titles>
  <contributors>
    <organization sequence='first' contributor_role='author'>Researcher, 10 William Ave, Greenlane, Auckland 1051, New Zealand</organization>
    <person_name sequence='first' contributor_role='author'>
     <given_name>James Russell</given_name>
      <surname>Farmer</surname>
      <ORCID>https://orcid.org/0000-0001-8131-8835</ORCID>
    </person_name>
  </contributors>
  <jats:abstract xml:lang='en'>
    <jats:p>This manuscript develops a theoretical framework in which irradiated metal complexes interact with cellular membranes through a dual-boundary energetic structure that enables selective intracellular trapping. Building on prior work in electromagnetic flux guidance, zero-resistivity domains, and discontinuity surfaces, the membrane is modelled as two discrete dissipative boundaries enclosing a low-loss interior. When a complex with initial kinetic energy E_0encounters the first boundary, an energy cost Was imposed; a second equivalent cost appears at the exit interface. The resulting inequality system divides motion into three non-overlapping regimes: rejection if E_0&lt;W, trapping if W&lt;E_0&lt;2W, and full transmission if E_0≥2W. In the trapping interval, the complex enters the interior but cannot exit because no real-valued propagation state remains after the second dissipation event. This produces directional asymmetry without invoking biochemical affinity entry and exit are not reversible operations, and confinement emerges from the disappearance of admissible solutions rather than from force, binding, or potential wells. The model therefore predicts a physically grounded mechanism by which pathological membranes with altered boundary cost Would, in principle, exhibit different trapping behavior than healthy cells. While no therapeutic or clinical claim is made, the analysis identifies measurable indicators boundary dissipation, interior continuity, and exit-state collapse that define how the hypothesis could be experimentally tested. The work concludes by framing this mechanism as a conditional, testable proposal in theoretical biophysics.</jats:p>
  </jats:abstract>
<publication_date media_type='online'>
    <month>12</month>
    <year>2025</year>
  </publication_date>  <pages>
  <first_page>48</first_page>
  <last_page>57</last_page>
  </pages>
  <doi_data>
  <doi>10.14331/ijfps.2025.330178</doi>
  <resource>https://www.fundamentaljournals.com/index.php/ijfps/article/view/264</resource>
  </doi_data>
</journal_article>
  </journal>
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